EVENT DATE: 7/14/2023
Dermatologists and rheumatologists often collaborate on the most complicated of autoimmune disease, including psoriasis and psoriatic arthritis. The Group for Research and Assessment in Psoriasis and Psoriatic Arthritis (GRAPPA), composed of both rheumatologists and dermatologists interested in curing psoriatic disease, held its annual meeting in Dublin Ireland from July 14-16, 2023. Dr. Sam Hwang was invited to give a plenary lecture on "Targeting psoriatic skin and joint disease through the chemokine receptor, CCR6", in which he outlined the rationale for blocking CCR6 with the CCL20 locked dimer as a novel potential treatment for these diseases which affects up to 3 percent of Americans.
EVENT DATE: 6/13/2023
Invited speaker, Gordon Research Conference on Molecular Pharmacology, Les Diablerets, Switzerland, “Conformational Selection in ACKR3 Activation and Inhibition by Ligands Large and Small”.
At the ENC conference in California and at the Molecular Pharmacology GRC in Switzerland a few months later, Dr. Volkman presented findings from a recent NMR study carried out in his MCW research lab on the conformational regulation of the atypical chemokine receptor 3 (ACKR3). These results, which were published last year in Science, demonstrate that recruitment of beta arrestin involves the dampening of internal motions to stabilize the active state of the receptor.